Men Who Benefit from Higher Doses of Naftopidil for Urinary Symptoms
Author Information
Author(s): Mizusawa Takaki, Hara Noboru, Obara Kenji, Isahaya Etsuko, Nakagawa Yuki, Takahashi Kota
Primary Institution: Niigata University
Hypothesis
Men with higher slow stream scores and unsatisfactory improvement in nocturia may benefit from dose escalation of naftopidil.
Conclusion
Men with high slow stream scores and unsatisfactory improvement in nocturia may benefit from increasing their dose of naftopidil.
Supporting Evidence
- The 75 mg group showed improvement in total IPSS and QOL scores in a dose-dependent manner.
- Patients with a baseline slow stream score of 3 or higher may benefit from dose escalation.
- Adverse effects were minimal and did not differ significantly between the two doses.
Takeaway
Some men have trouble urinating, and taking a higher dose of a medicine called naftopidil can help them feel better.
Methodology
53 men with lower urinary tract symptoms were treated with 50 mg of naftopidil for 4 weeks, then those unsatisfied with improvement increased to 75 mg for another 4 weeks.
Potential Biases
The small sample size in the 50 mg group may lead to bias in results.
Limitations
The small number of participants limited the study's capacity and evidence level.
Participant Demographics
The study included 53 men with moderate-to-severe lower urinary tract symptoms, average age 71.7 years.
Statistical Information
P-Value
P < .001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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