Producing Testosterone and Boldenone from Phytosterol Using Fungi
Author Information
Author(s): Vyacheslav V. Kollerov, Tatiana A. Timakova, Andrei A. Shutov, Marina V. Donova, Edvaldo Antonio Ribeiro Rosa, Sanjai Saxena
Primary Institution: Federal Research Center, Pushchino Center for Biological Research of Russian Academy of Sciences
Hypothesis
Can the ascomycete Curvularia sp. efficiently convert phytosterol into testosterone and boldenone through cascade biotransformations?
Conclusion
The study demonstrates that Curvularia sp. can effectively convert phytosterol into testosterone and boldenone, showcasing its biotechnological potential.
Supporting Evidence
- Curvularia sp. was shown to convert androstadienedione to yield 97% boldenone.
- The study developed a novel cascade biotransformation process for producing testosterone and boldenone from phytosterol.
- Six candidate genes encoding 17β-hydroxysteroid dehydrogenases were identified in the Curvularia sp. genome.
Takeaway
Scientists found a way to make important medicines from plants using a special fungus, which is good for the environment.
Methodology
The study involved using the fungus Curvularia sp. in combination with Mycolicibacterium strains to convert phytosterol into testosterone and boldenone through a two-step biotransformation process.
Limitations
The study did not explore the economic feasibility of the biotransformation process on a larger scale.
Digital Object Identifier (DOI)
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