Naringenin Protects Kidneys from Damage Caused by Dasatinib
Author Information
Author(s): Alhazzani Khalid, Alqarni Naif N., Aljerian Khaldoon, Raish Mohammad, Aljuffali Lobna, Alshehri Samiyah, Alanazi Ahmed Z.
Primary Institution: King Saud University
Hypothesis
Can naringenin mitigate kidney damage induced by dasatinib in a mouse model?
Conclusion
Naringenin effectively reduces kidney damage caused by dasatinib by improving antioxidant levels, reducing inflammation, and modulating apoptosis.
Supporting Evidence
- DASATINIB treatment increased kidney damage markers, which were reduced by naringenin.
- Naringenin restored antioxidant levels in kidney tissues after DASATINIB treatment.
- Naringenin reduced pro-inflammatory cytokines induced by DASATINIB.
- Naringenin modulated apoptotic protein expression in kidney tissues affected by DASATINIB.
Takeaway
This study shows that naringenin, a natural compound found in fruits, can help protect kidneys from damage caused by a cancer drug called dasatinib.
Methodology
Mice were treated with naringenin for one week before receiving dasatinib, and various kidney function biomarkers were measured.
Potential Biases
Potential bias due to the small sample size and lack of detailed mechanistic investigation.
Limitations
The study had a small sample size and only used a single dose of dasatinib, which may not reflect chronic exposure effects.
Participant Demographics
Male Swiss albino mice, aged 6-8 weeks, weighing 25-30 g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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