Genetic Factors and Heart Disease Risk
Author Information
Author(s): Kato Ikuko, Land Susan, Barnholtz-Sloan Jill, Severson Richard K.
Primary Institution: Wayne State University
Hypothesis
Are the FABP2 and APOE polymorphisms associated with histories of myocardial infarction, stroke, diabetes, and gallbladder disease?
Conclusion
The FABP2-T54 allele is a potential genetic marker for myocardial infarction, while the APOE4 isoform may increase the risk of myocardial infarction and decrease the risk of gallbladder disease in women.
Supporting Evidence
- The FABP2-T54 allele was associated with an increased risk of myocardial infarction (OR = 1.51).
- Subjects with APOE4 had a significantly increased risk of myocardial infarction (OR = 1.89).
- Gender interactions were significant for the effects of APOE on myocardial infarction and gallbladder disease.
Takeaway
Some genes can make you more likely to have heart problems or gallbladder issues, especially in women.
Methodology
This study analyzed data from a population-based case-control study, focusing on genetic polymorphisms and their associations with various diseases.
Potential Biases
Potential bias due to self-reported data and the exclusion of certain populations.
Limitations
Self-reported disease histories may lead to misclassification, and the study did not include fatal cases.
Participant Demographics
57% females, 43% males, 26.5% African Americans, 69.2% Non-Hispanic Caucasians.
Statistical Information
P-Value
0.029
Confidence Interval
1.01–2.27
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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