Antimicrobial Resistance in Tuberculosis Patients in Tanzania
Author Information
Author(s): Willy Urassa, Ferdinand Mugusi, Eduardo Villamor, Gernard Msamanga, Candida Moshiro, Ronald Bosch, Elmar Saathoff, Wafaie Fawzi
Primary Institution: Muhimbili University of Health and Allied Sciences
Hypothesis
What is the prevalence of primary antimicrobial resistance among Mycobacterium tuberculosis isolates from HIV seropositive and HIV seronegative patients in Dar es Salaam, Tanzania?
Conclusion
The primary resistance rate of M. tuberculosis in a selected population in Dar es Salaam, Tanzania is low.
Supporting Evidence
- Among 280 M. tuberculosis isolates tested, 14 were resistant to at least one anti-TB drug.
- The prevalence of primary resistance was 5.0% for isoniazid, 0.7% for streptomycin, and 0.4% for rifampicin.
- One isolate (0.4%) was identified as multidrug-resistant (MDR).
Takeaway
This study looked at how many tuberculosis germs are resistant to medicine in patients in Tanzania, and found that not many are resistant.
Methodology
Patients were tested for M. tuberculosis resistance using antimicrobial susceptibility testing on four drugs and HIV testing.
Potential Biases
The study may not reflect the prevalence of acquired resistance as it focused only on primary resistance.
Limitations
Patients with severe disease (Karnofsky score < 40%) were excluded, which may have omitted those with resistant strains.
Participant Demographics
280 patients, 191 (68%) males and 89 (32%) females, with 133 (47%) being HIV seropositive.
Statistical Information
P-Value
0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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