Impact of TRIM5α Variants on HIV-1 Progression
Author Information
Author(s): Valérie Goldschmidt, Gabriela Bleiber, Margaret May, Raquel Martinez, Millàn Ortiz, Amalio Telenti
Primary Institution: Institute of Microbiology and University Hospital, University of Lausanne, Switzerland
Hypothesis
Do common human TRIM5α variants affect HIV-1 disease progression?
Conclusion
Common human variants of TRIM5α have no effect or modest effect on HIV-1 disease progression.
Supporting Evidence
- The study included 979 untreated individuals infected with HIV-1.
- The median follow-up time was 3.2 years with 9,828 CD4 T cell measurements.
- Modest differences in disease progression were observed for certain TRIM5α variants.
Takeaway
This study looked at how certain changes in a protein called TRIM5α might affect how quickly people get sick from HIV. It found that these changes don't really make a difference.
Methodology
The study analyzed common amino acid variations in TRIM5α among 979 untreated HIV-1 infected individuals over a median follow-up of 3.2 years.
Limitations
The study's findings may not apply to all populations due to the specific cohort analyzed.
Participant Demographics
Cohort consisted of 979 untreated individuals infected with HIV-1, with a median follow-up of 3.2 years.
Statistical Information
P-Value
0.02
Confidence Interval
95% CI -1.39 to -2.09
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website