Astragalus-based Eefooton for Chronic Kidney Disease
Author Information
Author(s): Kuo-Cheng Lu, Ko-Lin Kuo, San-Chiang Wu, Chih-Hui Lin, Cheng-Ju Lin, Yi-Chou Hou, Jin-Shuen Chen
Primary Institution: Kaohsiung Veterans General Hospital
Hypothesis
Can Eefooton, a Traditional Chinese Medicine, improve kidney function in patients with chronic kidney disease?
Conclusion
Eefooton treatment significantly improved kidney function in patients with stage 3-5 chronic kidney disease without safety concerns.
Supporting Evidence
- Median eGFR improved from 34.37 to 42.47 mL/min/1.73 m2 after treatment.
- Improvements were significant across different CKD stages.
- No adverse events related to the treatment were reported.
- EFT enhanced HK-2 cell viability in vitro.
- EFT reduced fibrosis-related protein expression in treated cells.
Takeaway
This study shows that a herbal medicine called Eefooton can help people with kidney problems feel better and keep their kidneys working longer.
Methodology
A self-controlled, prospective study with 75 CKD patients receiving Eefooton for 6 months, assessing kidney function and conducting in vitro studies.
Potential Biases
Potential biases due to the non-randomized design and self-selection of participants.
Limitations
The study had a limited sample size and did not measure proteinuria changes.
Participant Demographics
75 patients (33 females, 42 males; mean age 68.20 years) with stage 3-5 CKD.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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