Calcium Prevents Colorectal Cancer in Mice
Author Information
Author(s): Wang Ji-Lin, Lin Yan-Wei, Chen Hui-Min, Kong Xuan, Xiong Hua, Shen Nan, Hong Jie, Fang Jing-Yuan
Primary Institution: Shanghai Jiao-Tong University School of Medicine, Renji Hospital
Hypothesis
Can calcium prevent colorectal cancer induced by 1,2-dimethylhydrazine in mice?
Conclusion
Calcium significantly reduced the incidence of colorectal cancer in mice and altered gene expression related to tumorigenesis.
Supporting Evidence
- The tumor incidence rates in the DMH and DMH + Calcium groups were 90% and 40%, respectively.
- Calcium altered the expression of genes related to tumorigenesis.
- Calcium was found to downregulate oncogenes and inhibit tumor-associated pathways.
Takeaway
This study found that giving mice calcium can help stop them from getting colon cancer.
Methodology
Mice were divided into four groups and treated with DMH and calcium to assess tumor incidence and gene expression.
Potential Biases
Potential bias due to the use of a specific mouse model and high calcium diet.
Limitations
The study used colorectal tissues instead of mucosa, which may affect gene origin determination, and the calcium content was high, which may not be applicable to humans.
Participant Demographics
80 female Slac: ICR mice, specific pathogen-free.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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