Efficacy and Safety of Derquantel-Abamectin in Sheep
Author Information
Author(s): Little PR, Hodge A, Watson TG, Seed JA, Maeder SJ
Primary Institution: Pfizer Animal Health
Hypothesis
To evaluate the efficacy and safety of the novel anthelmintic combination, derquantel-abamectin, against gastrointestinal nematode populations in sheep, under field-use conditions.
Conclusion
Derquantel-abamectin is highly effective for treating gastrointestinal nematodes in sheep, including resistant populations.
Supporting Evidence
- The efficacy of derquantel-abamectin against mixed strongyle populations was ≥99.2%.
- In trials with Nematodirus sp., derquantel-abamectin was 100% effective.
- Mean bodyweight gain was significantly greater in the derquantel-abamectin group than in negative controls in five trials.
Takeaway
This study shows that a new medicine for sheep can kill bad worms that make them sick, even when other medicines don't work anymore.
Methodology
Controlled faecal egg count reduction tests (FECRT) were conducted in 14 trials across various farms in New Zealand.
Limitations
The study may not represent all sheep farms due to specific geographic and management conditions.
Participant Demographics
Sheep aged 2-12 months, weighing 18.5-53.0 kg, from various breeds.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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