How Should the Impact of Different Presentations of Treatment Effects on Patient Choice Be Evaluated? A Pilot Randomized Trial Evaluating Risk Communication
2008

Evaluating Risk Communication in Treatment Decisions

Sample size: 770 publication Evidence: moderate

Author Information

Author(s): Cheryl Carling, Doris Tove Kristoffersen, Jeph Herrin, Shaun Treweek, Andrew D. Oxman, Holger Schünemann, Elie Akl, Victor Montori

Primary Institution: Norwegian Knowledge Centre for the Health Services, Oslo, Norway

Hypothesis

Different presentations of treatment effects can influence patient decisions.

Conclusion

Internet-based trials comparing different presentations of treatment effects are feasible, but recruiting participants is a major challenge.

Supporting Evidence

  • Participants preferred the relative risk reduction (RRR) presentation over other statistics.
  • The odds of deciding to take statins were significantly higher in the RRR group.
  • Recruitment challenges were noted in conducting Internet-based trials.

Takeaway

This study looked at how different ways of showing treatment benefits can change people's decisions about taking medicine. It found that people were more likely to choose to take statins when shown certain types of information.

Methodology

An Internet-based randomized trial comparing summary statistics for communicating the effects of statins on coronary heart disease risk.

Potential Biases

Participants with higher education or scientific backgrounds were less likely to decide to take statins.

Limitations

Recruitment of participants was a major challenge, and the applicability of results to different populations is uncertain.

Participant Demographics

58% women, 62% aged 40-59, 47% with 17+ years of education, 84% from the USA.

Statistical Information

P-Value

p=0.0007

Confidence Interval

95% CI 0.006 to 0.025

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1371/journal.pone.0003693

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