Claudin-7 Is Frequently Overexpressed in Ovarian Cancer and Promotes Invasion
2011
Claudin-7 and Its Role in Ovarian Cancer
Sample size: 95
publication
Evidence: high
Author Information
Author(s): Neetu Dahiya, Kevin G. Becker, William H. Wood III, Yongqing Zhang, Patrice J. Morin
Primary Institution: National Institute on Aging, Baltimore, Maryland, United States of America
Hypothesis
Claudin-7 is frequently upregulated in ovarian cancer and may play a role in cancer invasion.
Conclusion
Claudin-7 is significantly upregulated in ovarian cancer and may be involved in promoting invasion.
Supporting Evidence
- Claudin-7 was found to be upregulated in all ovarian cancer subtypes studied.
- Knockdown of claudin-7 in ovarian cancer cells led to significant changes in gene expression.
- Invasion assays showed that claudin-7 promotes the invasive potential of ovarian cancer cells.
Takeaway
Claudin-7 is a protein that helps cells stick together, and in ovarian cancer, it can help the cancer spread.
Methodology
The study analyzed 95 ovarian tissue samples for claudin-7 expression using RT-PCR, immunohistochemistry, and western blotting.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website