Study of Picrorhiza kurroa Extracts in Fatty Liver Disease
Author Information
Author(s): Shetty Sapna N., Mengi Sushma, Vaidya Rama, Vaidya Ashok D.
Primary Institution: Medical Research Centre, Kasturba Health Society, Mumbai, India
Hypothesis
Can standardized extracts of Picrorhiza kurroa reverse fatty changes in the liver caused by a high-fat diet?
Conclusion
The study found that Picrorhiza kurroa extracts significantly reduced liver fat content and improved liver structure in a rat model of non-alcoholic fatty liver disease.
Supporting Evidence
- The extract of Picrorhiza kurroa significantly reduced liver lipid content compared to the high-fat diet control group.
- Histopathological analysis showed improved liver architecture in the treatment groups.
- Both doses of Picrorhiza kurroa were effective, with the higher dose showing greater lipid reduction.
Takeaway
This study shows that a plant called Picrorhiza kurroa can help make sick livers healthier in rats that ate a lot of fat.
Methodology
Male Wistar rats were fed a high-fat diet to induce non-alcoholic fatty liver disease and treated with hydroalcoholic extracts of Picrorhiza kurroa for 4 weeks.
Limitations
The study was conducted on rats, and results may not directly translate to humans.
Participant Demographics
Male Wistar rats, weighing 200-250 g.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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