Exosomes, their sources, and possible uses in cancer therapy in the era of personalized medicine
2024

Exosomes in Cancer Therapy

publication 10 minutes Evidence: moderate

Author Information

Author(s): Tomas Zemanek, Lubos Danisovic, Andreas Nicodemou

Primary Institution: Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, Bratislava, Slovakia

Hypothesis

Exosomes can enhance the effectiveness of immunotherapy for solid tumors.

Conclusion

Exosomes have significant potential in cancer diagnosis, treatment, and prognosis, particularly in enhancing immunotherapy effectiveness.

Supporting Evidence

  • Exosomes can transport diverse intracellular molecules to nearby or distant cells, facilitating numerous biological functions.
  • Research has shown that exosomes can both activate and suppress the immune system.
  • Exosomes derived from various bodily fluids serve as promising biomarkers for cancer diagnosis and prognosis.
  • Recent advancements in exosome-based therapy highlight its utility in drug delivery and immunotherapy.

Takeaway

Exosomes are tiny bubbles that can carry important signals in the body, and scientists think they can help treat cancer better by improving how our immune system fights tumors.

Methodology

This review examines the composition and sources of exosomes and their impact on immunotherapy in solid tumors.

Limitations

The review does not provide specific experimental data or clinical trial results.

Digital Object Identifier (DOI)

10.1007/s00432-024-06066-w

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