Effects of Bifidobacterium infantis and Oligofructose on Colitis in Rats
Author Information
Author(s): Osman Nadia, Adawi Diya, Molin Göran, Ahrne Siv, Berggren Anna, Jeppsson Bengt
Primary Institution: Lund University, Sweden
Hypothesis
Can Bifidobacterium infantis and oligofructose improve inflammation in colitis?
Conclusion
Bifidobacterium infantis and oligofructose significantly improve DSS-induced acute colitis and reduce inflammation.
Supporting Evidence
- DAI decreased significantly in all treatment groups compared to colitis control.
- MPO activity decreased significantly in all groups compared to the colitis control group.
- MDA levels decreased significantly in B. infantis DSM 15159 groups with and without OFI compared to colitis control.
- Bacterial translocation to mesenteric lymph nodes decreased significantly in all groups compared to colitis control.
Takeaway
Giving certain good bacteria and fiber to rats with gut inflammation helped them feel better and reduced their sickness.
Methodology
Rats were divided into groups and treated with Bifidobacterium infantis and oligofructose before and after inducing colitis with DSS.
Limitations
The study was conducted on rats, which may not fully represent human responses.
Participant Demographics
Sprague-Dawley rats, 200g each.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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