Vitamin D Receptor Gene Polymorphisms in Thai Patients with Systemic Lupus Erythematosus
Author Information
Author(s): Sakulpipatsin Wilaiporn, Verasertniyom Oravan, Nantiruj Kanokrat, Totemchokchyakarn Kitti, Lertsrisatit Porntawee, Janwityanujit Suchela
Primary Institution: Mahidol University
Hypothesis
What are the characteristics of VDR gene BsmI polymorphisms in patients with SLE and their relationship to susceptibility and clinical manifestations?
Conclusion
There is no association between VDR gene BsmI polymorphisms and systemic lupus erythematosus in Thai patients.
Supporting Evidence
- The distribution of VDR genotyping in patients with SLE was 1.9% for BB, 21.78% for Bb, and 76.23% for bb.
- The distribution of VDR genotyping in the control group was 1.03% for BB, 15.98% for Bb, and 82.99% for bb.
- There was no statistically significant difference between the two groups (p = 0.357).
- The allelic distribution of B and b was similar within the groups (p = 0.173).
- The relationship between VDR genotype and clinical manifestation or laboratory profiles of SLE cannot be statistically demonstrated.
Takeaway
The study looked at a gene related to vitamin D in people with a disease called lupus, but found no link between the gene and the disease.
Methodology
VDR genotyping was performed using PCR-RFLP on DNA from 101 patients with SLE and 194 healthy controls.
Limitations
The study may not represent all populations, and a larger study is needed to examine other VDR gene polymorphisms.
Participant Demographics
All participants were females older than 15 years of age.
Statistical Information
P-Value
0.357
Statistical Significance
p = 0.357
Digital Object Identifier (DOI)
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