Multimorbidity and Kidney Function Decline in Older Adults
Author Information
Author(s): Beridze Giorgi, Dai Lu, Carrero Juan-Jesús, Marengoni Alessandra, Vetrano Davide Liborio, Calderón-Larrañaga Amaia
Primary Institution: Karolinska Institutet
Hypothesis
There is an association between multimorbidity and the risk of kidney function decline in older adults.
Conclusion
Multimorbidity is strongly associated with accelerated kidney function decline in older age, particularly in individuals with cardiometabolic conditions.
Supporting Evidence
- There was a dose-response relationship between the number of chronic conditions and declines in kidney function.
- The Unspecific, high burden and Cardiometabolic patterns showed accelerated declines in kidney function.
- The Cognitive and Sensory pattern also showed accelerated relative decline.
Takeaway
Having multiple health problems can make your kidneys work worse as you get older, especially if you have heart and metabolic issues.
Methodology
The study followed 3094 individuals from the Swedish National Study on Aging and Care in Kungsholmen between 2001 and 2016, using joint models and Cox regression to analyze the data.
Participant Demographics
Mean age of the sample was 73.9 years, with 87% having multimorbidity.
Statistical Information
Confidence Interval
95% CI
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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