Structure and Evolution of CDGSH Iron-Sulfur Domains
Author Information
Author(s): Lin Jinzhong, Zhang Liman, Lai Shaomei, Ye Keqiong
Primary Institution: National Institute of Biological Sciences, Beijing, China
Hypothesis
How do different types of CDGSH iron-sulfur domains (CISDs) differ in structure and evolutionary relationships?
Conclusion
The study reveals that all CISDs share a common ancestry and diverged into three primary folds with distinct phylogenetic distributions.
Supporting Evidence
- The crystal structures of type 3, 4, and 6 CISDs were determined at high resolutions.
- CISDs are classified into seven major types with a wide distribution across life forms.
- The study provides insights into the evolutionary relationships of CISDs.
Takeaway
Scientists studied special proteins called CISDs that help with iron and sulfur in cells. They found that these proteins have different shapes but are related to each other.
Methodology
The researchers determined the crystal structures of type 3, 4, and 6 CISDs using X-ray crystallography.
Limitations
The study primarily focuses on only three types of CISDs and may not represent all variations.
Digital Object Identifier (DOI)
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