Caveolin 1 and Caveolin 2 in Breast Cancer
Author Information
Author(s): Elsheikh S E, Green A R, Rakha E A, Samaka R M, Ammar A A, Powe D, Reis-Filho J S, Ellis I O
Primary Institution: Department of Histopathology, School of Molecular Medical Sciences, Nottingham, UK
Hypothesis
CAV1 and CAV2 expressions are associated with the basal-like phenotype in breast cancer.
Conclusion
CAV1 and CAV2 are associated with basal-like phenotype in breast cancer, but further studies are needed to clarify their role in cancer development.
Supporting Evidence
- CAV1 and CAV2 expression was observed in 13.4% and 5.9% of all breast cancer cases, respectively.
- Both proteins were significantly associated with high histological grade and lack of steroid hormone receptor positivity.
- CAV2 had a prognostic impact on breast cancer-specific survival in univariate analysis.
Takeaway
This study looked at two proteins, CAV1 and CAV2, in breast cancer to see if they are linked to a specific type of cancer that is harder to treat.
Methodology
CAV1 and CAV2 expression was assessed using immunohistochemistry on a tissue microarray of 880 invasive breast cancer cases.
Potential Biases
Potential bias due to the retrospective nature of the study and the limited number of certain patient groups.
Limitations
The study is retrospective and exploratory, and the number of patients with grade 1, CAV1-positive breast cancers was limited.
Participant Demographics
Patients diagnosed with invasive breast cancer between 1986 and 1998.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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