The Role of EBV and DNA Topoisomerase II in Oral Cancer
Author Information
Author(s): Shamaa Ali A, Zyada Manal M, Wagner Mathias, Awad Sally S, Osman Mohamed M, Azeem Ali A Abdel
Primary Institution: Oral Biology Department, Faculty of Dentistry, Minia University, Minia, Egypt
Hypothesis
This study investigates the role of EBV and DNA Topoisomerase IIα during oral carcinogenesis and examines the prognostic significance of these protein expressions in oral squamous cell carcinomas.
Conclusion
EBV and DNA Topo II-αLI expression are possible indicators in oral carcinogenesis and may be valuable diagnostic and prognostic indices in oral carcinoma.
Supporting Evidence
- DNA-Topo IIα was expressed in all examined specimens.
- Significant differences were observed between OEDs and normal squamous epithelium.
- EBV expression was increased with elevated Topo II-α LI in OEDs and OSCCs.
Takeaway
This study looked at how two proteins, EBV and DNA Topo II, might help doctors understand and predict oral cancer better.
Methodology
Immunohistochemistry was used to examine protein expressions in archival lesion tissues from patients with oral epithelial dysplasia, oral squamous cell carcinoma, and normal oral mucosa.
Participant Demographics
38 patients (12 women and 26 men) treated for primary SCC of the oral cavity and premalignant oral lesions.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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