Genetic Variation in Indian-Origin Rhesus Macaques
Author Information
Author(s): Fawcett Gloria L, Raveendran Muthuswamy, Deiros David Rio, Chen David, Yu Fuli, Harris Ronald Alan, Ren Yanru, Muzny Donna M, Reid Jeffrey G, Wheeler David A, Worley Kimberly C, Shelton Steven E, Kalin Ned H, Milosavljevic Aleksandar, Gibbs Richard, Rogers Jeffrey
Primary Institution: Baylor College of Medicine
Hypothesis
Genome-wide knowledge of SNP variation in Indian-origin rhesus macaques will provide valuable information about functionally significant genetic variation.
Conclusion
The study identified over 3 million SNPs in Indian-origin rhesus macaques, providing a significant resource for genetic research and potential models for human disease.
Supporting Evidence
- More than 3 million SNPs were validated across the genome.
- Over 700 non-synonymous SNPs were identified as possibly or probably damaging to protein function.
- The study provides a new resource for genetic studies related to health and disease in rhesus macaques.
- High genetic variation was observed in the Indian-origin rhesus macaques.
Takeaway
Scientists found a lot of tiny differences in the genes of Indian monkeys, which can help us understand diseases that also affect humans.
Methodology
The study used whole genome re-sequencing and various bioinformatics methods to validate SNPs across three Indian-origin rhesus macaques.
Limitations
The study is not exhaustive, and further validation of potential SNPs is needed.
Participant Demographics
Three Indian-origin rhesus macaques were used in the study.
Digital Object Identifier (DOI)
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