Lactobacillus Mixtures and Banaba Leaf Extract Help Reduce Obesity in Mice
Author Information
Author(s): Lee Kippeum, Kim Hyeon-Ji, Kim Joo Yun, Shim Jae Jung, Lee Jae Hwan
Primary Institution: R&BD Center, hy Co., Ltd.
Hypothesis
Can a combination of Lactobacillus mixtures and Lagerstroemia speciosa leaf extract prevent obesity in high-fat diet-fed mice?
Conclusion
The combination of Lactobacillus mixtures and Lagerstroemia speciosa leaf extract significantly reduced weight gain and fat tissue expansion in obese mice.
Supporting Evidence
- The combination treatment reduced body weight gain in mice fed a high-fat diet.
- Fat tissue expansion was significantly inhibited by the treatment.
- Serum glucose and insulin levels were reduced in treated mice.
- Gene expression related to fat storage was altered favorably by the treatment.
Takeaway
This study found that giving mice a mix of good bacteria and a plant extract helped them not gain as much weight when they ate a lot of fat.
Methodology
Mice were fed a high-fat diet and treated with Lactobacillus mixtures and leaf extract for 5 weeks, with body mass and fat tissue measured.
Potential Biases
Potential bias due to the authors' affiliation with the company that provided the Lactobacillus strains.
Limitations
The study was conducted only on mice, and results may not directly translate to humans.
Participant Demographics
Male 6-week-old C57Bl/6 mice.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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