Biochemical and Hematological Markers for Diagnosing Hepatitis C
Author Information
Author(s): Saeede Bagheri, Ghazaleh Behrouzian Fard, Nasrin Talkhi, Davoud Rashidi Zadeh, Naser Mobarra, Seyedmahdi Mousavinezhad, Fatemeh Mirzaeian Khamse, Mahdi Hosseini Bafghi
Primary Institution: Mashhad University of Medical Sciences
Hypothesis
Can biochemical and hematological parameters serve as early predictive biomarkers for diagnosing Hepatitis C virus infection?
Conclusion
The study found significant differences in biochemical and hematological markers between HCV patients and healthy individuals, which are crucial for early diagnosis.
Supporting Evidence
- Biochemical and hematological parameters were significantly different between HCV patients and healthy controls.
- ROC curve analysis showed that certain blood markers are strong predictors for Hepatitis C infection.
- Elevated levels of SGPT, LDH, TBIL, and ferritin were found in HCV patients.
Takeaway
Doctors can use certain blood tests to tell if someone has Hepatitis C, which can help catch the disease early and prevent serious liver problems.
Methodology
The study analyzed 100 HCV-positive patients and 100 HCV-negative controls using various blood tests and ROC curve analysis.
Limitations
The study did not explore the effects of antiviral treatments on the identified biomarkers and lacked long-term follow-up on treatment outcomes.
Participant Demographics
76% male and 24% female among HCV-positive patients.
Statistical Information
P-Value
p<0.0001
Confidence Interval
95% confidence interval for significant parameters ranged from 0.498 to 1.000.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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