Can Meglumine Antimoniate Treatment Cause Pancreatitis in Dogs with Leishmaniosis?
Author Information
Author(s): Viñeta Clàudia, Castro Jorge, López María Cristina, Frau Maria, Costas Antón, Arenas Carolina, Roura Xavier
Primary Institution: Hospital Clínic Veterinari, Universitat Autònoma de Barcelona, Bellaterra, Spain
Hypothesis
Can treatment with meglumine antimoniate induce pancreatitis in dogs with leishmaniosis?
Conclusion
Meglumine antimoniate can induce pancreatitis in a significant percentage of dogs with leishmaniosis, especially those in advanced clinical stages.
Supporting Evidence
- 14 out of 33 dogs developed pancreatitis during the study.
- Advanced LeishVet clinical stage was statistically associated with the development of pancreatitis.
- Monitoring serum cPLI levels and performing abdominal ultrasound is recommended for dogs showing clinical signs of pancreatitis.
Takeaway
This study found that a medicine used to treat sick dogs can sometimes make their tummies hurt, especially if they are really sick already.
Methodology
A multicentric, prospective, observational study was conducted from April 2021 to February 2023, involving 33 dogs with leishmaniosis.
Potential Biases
Potential bias due to the multicentric nature and variability in dog demographics.
Limitations
The study had a small sample size and lacked a control group, and histopathology was not performed.
Participant Demographics
33 dogs, 22 male (12 entire, 10 neutered), 11 female (8 spayed, 3 entire), median age 7.2 years.
Statistical Information
P-Value
0.002
Confidence Interval
95% CI
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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