Effects of Co-Amorphous Naringenin and Fisetin on Obesity in Mice
Author Information
Author(s): Sarai Vásquez-Reyes, Miranda Bernal-Gámez, Jorge Domínguez-Chávez, Karina Mondragón-Vásquez, Mónica Sánchez-Tapia, Guillermo Ordaz, Omar Granados-Portillo, Diana Coutiño-Hernández, Paulina Barrera-Gómez, Nimbe Torres, Armando R. Tovar
Primary Institution: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico
Hypothesis
Can co-amorphous naringenin or fisetin with enhanced solubility improve glucose and lipid metabolism, thermogenic capacity, and gut microbiota in mice on a high-fat diet?
Conclusion
Co-amorphous naringenin and fisetin show potential in improving metabolic health and reducing fat mass in mice fed a high-fat diet.
Supporting Evidence
- CoA-naringenin reduced fat mass gain by 45% compared to the high-fat diet group.
- CoA-naringenin improved cholesterol metabolism and glucose tolerance in mice.
- Both CoA-flavonoids increased oxygen consumption, enhancing energy expenditure.
- CoA-fisetin activated thermogenic markers in adipose tissue.
Takeaway
This study found that special forms of two natural compounds, naringenin and fisetin, can help mice stay healthier and gain less weight when they eat a fatty diet.
Methodology
Mice were fed a high-fat, high-sucrose diet with or without co-amorphous naringenin or fisetin for 3 months, and various metabolic parameters were assessed.
Limitations
The study did not include unmodified compounds for comparison, limiting the ability to determine the specific effects of the co-amorphous forms.
Participant Demographics
8-week-old male C57BL/6 mice weighing 22–25 g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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