Metal Complexes of 5-Carboxy-2-Thiouracil and Their Antitumour Activity
Author Information
Author(s): Udai P. Singh, Sudha Singh, Sukh Mahendra Singh
Primary Institution: Department of Chemistry, University of Roorkee
Hypothesis
The study investigates the antitumour activity of metal complexes of 5-carboxy-2-thiouracil against Sarcoma-180 tumour cells.
Conclusion
Some metal complexes of 5-carboxy-2-thiouracil exhibit significant antitumour activity against Sarcoma-180 tumour cells.
Supporting Evidence
- Co(II), Ni(II), and Cu(II) complexes showed significant antitumour activity.
- 5CTU has an antitumour activity with a T/C value of 115 at a dose of 25.0 mg/kg.
- None of the test compounds were toxic up to the dose of 50.0 mg/kg except for Cd(II)-5CTU.
Takeaway
The researchers made special metal compounds and found that some of them can help fight a type of cancer in mice.
Methodology
Metal complexes were synthesized and tested for antitumour activity against Sarcoma-180 tumour cells in vivo and in vitro.
Limitations
The mechanism of antitumour action is not well understood, and some complexes were toxic at low doses.
Participant Demographics
Mice were used for testing the antitumour activity.
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