Activation of murine 'T' lymphomas in the presence of a human myeloma cell line, RPMI-8226, in vivo
1988
Activation of Murine T Lymphomas in Mice with Human Myeloma Cells
Sample size: 18
publication
Evidence: moderate
Author Information
Author(s): B.C. Millar, J.L. Millar, A. Jones, S.W. Feary, D. Robertson, J.B.G. Bell
Primary Institution: Institute of Cancer Research and Royal Marsden Hospital
Hypothesis
Can human myeloma cells activate murine leukaemia viruses in athymic nude mice?
Conclusion
The study found that human myeloma cells can lead to the growth of murine T lymphomas in athymic nude mice.
Supporting Evidence
- Tumors were palpable at injection sites after 12 days.
- All tumors were confirmed to be murine T lymphomas.
- The study showed that human myeloma cells can activate murine leukaemia viruses.
Takeaway
When scientists put human cancer cells in mice, sometimes the mice's own cancer cells grow instead.
Methodology
The study involved injecting human myeloma cells into athymic nude mice and monitoring tumor growth.
Limitations
The rapid growth of tumors may have prevented the observation of metastatic spread.
Participant Demographics
26-8 week-old male BALB/c athymic nude mice were used.
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