Gut Microbiome and Recurrent Urinary Tract Infections
Author Information
Author(s): Brigida Mattia, Saviano Angela, Petruzziello Carmine, Manetti Luca Luigi, Migneco Alessio, Ojetti Veronica
Primary Institution: Policlinico Tor Vergata, Rome, Italy
Hypothesis
The gut microbiota plays a significant role in the pathogenesis and recurrence of urinary tract infections (UTIs).
Conclusion
The study highlights the importance of gut microbiota in recurrent UTIs and suggests that probiotics may offer new therapeutic options.
Supporting Evidence
- Over 150 million people are affected by UTIs globally each year.
- Women are disproportionately affected by recurrent UTIs, with a prevalence of over 50%.
- Antibiotic treatments can lead to resistant strains, complicating UTI management.
- Probiotics may help restore gut balance and prevent recurrent UTIs.
Takeaway
This study shows that the bacteria in our gut can affect our chances of getting urinary infections, and using good bacteria (probiotics) might help prevent them.
Methodology
A narrative review of studies published in the last twenty years on the association between gut microbiota and urinary microbiome.
Potential Biases
Potential biases due to the inclusion of studies with varying methodologies and quality.
Limitations
The review is limited by the variability in study designs and probiotic strains used, and the scarcity of randomized controlled trials.
Participant Demographics
The review includes studies primarily focused on women with recurrent UTIs.
Digital Object Identifier (DOI)
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