Atorvastatin Gel for Treating Peri-Implant Mucositis
Author Information
Author(s): Khorramdel Azin, Mogharrab Alile Katayoun, Kananizadeh Yousef, Mousavi Seyed Amin, Molavi Fatima
Primary Institution: Tabriz University of Medical Sciences
Hypothesis
Does atorvastatin gel improve the treatment outcomes of peri-implant mucositis when used alongside mechanical debridement?
Conclusion
Using atorvastatin gel with mechanical debridement significantly improved clinical parameters associated with peri-implant mucosal inflammation.
Supporting Evidence
- Statistically significant improvements in clinical parameters were observed at multiple time points.
- Atorvastatin gel showed better outcomes compared to placebo in reducing inflammation.
- The study supports the use of atorvastatin gel as an adjunctive treatment for peri-implant mucositis.
Takeaway
This study found that applying a special gel with atorvastatin helps make gums around dental implants healthier when combined with cleaning.
Methodology
A double-masked, randomized clinical trial with 49 patients divided into two groups receiving either atorvastatin gel or placebo after mechanical debridement.
Potential Biases
Potential bias due to the knowledge of the researcher regarding the interventions administered.
Limitations
The study had a small sample size and short follow-up duration.
Participant Demographics
49 patients (20 males and 29 females) aged 40–60 years with peri-implant mucositis.
Statistical Information
P-Value
P≤0.001 for CAL and POP improvements; P<0.05 for PD and BOP at specified time points.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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