Assessing the BED HIV-1 Incidence Assay in Thailand
Author Information
Author(s): Janet M. McNicholl, J. Steven McDougal, Punneeporn Wasinrapee, Bernard M. Branson, Michael Martin, Jordan W. Tappero, Philip A. Mock, Timothy A. Green, Dale J. Hu, Bharat Parekh
Primary Institution: Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention
Hypothesis
The study aims to evaluate the performance of the BED assay in estimating HIV-1 incidence in different cohorts in Thailand.
Conclusion
The BED incidence estimates are comparable to conventional estimates when adjusted for long-term infections.
Supporting Evidence
- The BED assay was tested on specimens from three cohorts in Thailand.
- BED incidence estimates were similar to conventional estimates when only newly infected persons were tested.
- Including long-term infections inflated the BED incidence estimates.
Takeaway
This study looked at a test to see how many people are newly infected with HIV, and found that it works well when you include people who have been infected for a long time.
Methodology
The study used longitudinal cohorts and compared BED assay results with conventional incidence estimates.
Potential Biases
Potential biases include enrollment bias and loss to follow-up.
Limitations
The study may be limited by the presence of long-term infections that could affect the accuracy of the BED assay.
Participant Demographics
Participants included military conscripts and injection drug users in Thailand.
Statistical Information
Statistical Significance
p>0.05
Digital Object Identifier (DOI)
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