Tumor Markers in Bladder Cancer: Bilharzial vs Non-Bilharzial
Author Information
Author(s): Metwally Nadia S, Ali Sanaa A, Mohamed Azza M, Khaled Hussein M, Ahmed Samia A
Primary Institution: National Cancer Institute, Cairo, Egypt
Hypothesis
The study aims to elucidate the biochemical tumor markers in schistosomal bladder cancer compared to non-schistosomal bladder cancer.
Conclusion
Bilharzial and non-bilharzial bladder cancer exhibit distinct biochemical profiles that can aid in diagnosis.
Supporting Evidence
- Bilharzial bladder cancer patients showed significant elevation in serum XO, fructosamine, LDH, AST, ALT, hydroxyproline, IgE, and TNF-α compared to controls.
- Significant increases in PK, LDH, AST, and ALT activities were observed in schistosomal bladder cancer tissues compared to healthy tissues.
- Fructosamine levels were significantly higher in both bilharzial and non-bilharzial bladder cancer patients compared to healthy controls.
Takeaway
This study looked at different markers in patients with bladder cancer to see how they differ between those with a parasite infection and those without.
Methodology
The study analyzed tissue and serum samples from 55 bladder cancer patients and 10 healthy controls, measuring various biochemical markers.
Potential Biases
Potential biases may arise from the selection of patients and the control group.
Limitations
The study is limited to a specific population and may not be generalizable to other regions.
Participant Demographics
Participants included 55 Egyptian bladder cancer patients, with a mix of males and females aged 16 to 68.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website