Comprehensive Review on Neprilysin Inhibitors
Author Information
Author(s): Zhang Xinyue, Hu Chun, Tian Erkang, Shen Yanxin, Liu Wei, Li Juan
Primary Institution: Chengdu University of TCM, Chengdu, Sichuan, China; Sichuan University, Chengdu, Sichuan, China
Conclusion
Neprilysin inhibitors show promise in treating various diseases, including cardiovascular and Alzheimer's diseases, but they also have potential adverse effects.
Supporting Evidence
- NEP inhibitors can enhance the activity of beneficial peptides, which may help in treating cardiovascular diseases.
- Some NEP inhibitors have been linked to adverse reactions like hypotension and renal impairment.
- Research indicates that NEP plays a significant role in the metabolism of various bioactive peptides.
Takeaway
Neprilysin inhibitors help keep important body chemicals active, which can help treat heart and brain diseases, but they can also cause side effects.
Methodology
This review summarizes the progress on single-target and dual-target NEP inhibitors, detailing their design strategies, structure-activity relationships, and clinical performance.
Limitations
The review highlights the need for careful monitoring of physiological indicators and dosage adjustments due to potential side effects of NEP inhibitors.
Digital Object Identifier (DOI)
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