SHV Lactamase Engineering Database: A Tool for SHV β-lactamases
Author Information
Author(s): Thai Quan K, Pleiss Juergen
Primary Institution: Institute of Technical Biochemistry, University of Stuttgart
Hypothesis
The SHV β-Lactamase Engineering Database (SHVED) can reconcile inconsistencies in SHV β-lactamase annotations and identify new variants.
Conclusion
The SHVED contains reconciled information about SHV variants and helps identify new mutations, supporting the study of SHV β-lactamases.
Supporting Evidence
- The SHVED contains 200 protein entries with distinct sequences and 20 crystal structures.
- It reconciles 27 protein entries with inconsistent annotations.
- The database is updated monthly and provides data for download.
Takeaway
The SHV Lactamase Engineering Database helps scientists find and fix mistakes in SHV β-lactamase information and discover new types.
Methodology
The SHVED was developed by collecting SHV β-lactamase sequences from the NCBI protein database and the SHV mutation table, reconciling inconsistencies through systematic comparison.
Limitations
Some sequences are fragments and cannot be assigned new SHV numbers due to missing information.
Digital Object Identifier (DOI)
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