Modeling SNP Effects in Linkage Studies
Author Information
Author(s): Houwing-Duistermaat Jeanine J, Uh Hae-Won, Lebrec Jeremie JP, Putter Hein, Hsu Li
Primary Institution: Leiden University Medical Center
Hypothesis
Does the associated single-nucleotide polymorphism partly explain the original linkage peak?
Conclusion
SNP B03T3056 only partly explains the original linkage peak, and other unknown genetic factors are likely present.
Supporting Evidence
- The study applied methods to three SNPs and five microsatellite markers.
- SNP B03T3056 was significantly associated with the disease.
- Including the number of risk alleles increased the LOD score significantly.
Takeaway
The study looked at whether a specific genetic marker helps explain a genetic link to a disease. It found that while it does help a little, there are likely other factors involved.
Methodology
A regression model was used to analyze the relationship between SNP genotypes and linkage signals in affected sibling pairs.
Limitations
The analysis does not support the hypothesis of residual linkage, and more research is needed to understand the observed phenomena.
Statistical Information
P-Value
0.02
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website