Water-Soluble Extract of Pacific Krill Prevents Triglyceride Accumulation in Adipocytes by Suppressing PPARγ and C/EBPα Expression
2011
Pacific Krill Extract Prevents Fat Accumulation
Sample size: 10
publication
Evidence: high
Author Information
Author(s): Yamada Hidetoshi, Ueda Tomohiro, Yano Akira
Primary Institution: Iwate Biotechnology Research Center
Hypothesis
Does the water-soluble extract of Pacific Krill suppress triglyceride accumulation in adipocytes?
Conclusion
The water-soluble extract of Pacific Krill prevents triglyceride accumulation in adipocytes by suppressing PPARγ and C/EBPα expression.
Supporting Evidence
- The extract suppressed triglyceride accumulation in a dose-dependent manner.
- PPARγ and C/EBPα mRNA levels were significantly lower in treated cells.
- The extract was more effective than a PPARγ antagonist in suppressing fat accumulation.
Takeaway
Eating Pacific Krill can help stop fat from building up in your body by blocking certain signals that tell your body to store fat.
Methodology
The study involved culturing 3T3-F442A cells with the water-soluble extract of Pacific Krill and measuring triglyceride accumulation and gene expression.
Statistical Information
P-Value
0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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