Extent of the Acidification by N7-Coordinated cis-Diamine-Platinum(II) on the Acidic Sites of Guanine Derivatives
1996
Acidification Effects of N7-Coordinated cis-Diamine-Platinum(II) on Guanine Derivatives
Sample size: 18
publication
Evidence: moderate
Author Information
Author(s): Bin Song, Gerda Oswald, Matthias Bastian, Helmut Sigel, Bernhard Lippert
Primary Institution: Institute of Inorganic Chemistry, University of Basel
Hypothesis
How does N7-coordination of cis-(NH3)2Pt2+ affect the acid-base properties of guanine derivatives?
Conclusion
N7-coordinated cis-(NH3)2Pt2+ significantly acidifies the H(N1) sites of guanine residues while having a minimal effect on the basicity of phosphate residues.
Supporting Evidence
- N7-coordinated Pt2+ acidifies phosphate protons by an average of 0.36 pKa.
- The acidity constants for the complexes were determined through titration experiments.
- Significant acidification of H(N1) sites suggests enhanced hydrogen bonding potential.
- Coordination chemistry of cis-diammine-platinum(II) with nucleobases has been extensively studied.
Takeaway
This study shows that a certain type of platinum compound can change how acidic parts of DNA are, making them better at donating protons.
Methodology
Potentiometric pH titrations were used to measure acidity constants of the complexes formed between cis-(NH3)2Pt2+ and guanine derivatives.
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