Impact of APOA5 Gene Polymorphism on Serum Lipids in Koreans
Author Information
Author(s): Kwang Hoon Song, Sung-Gon Cha, Seongwon Kim, Jong Yeol Kim
Primary Institution: Korea Institute of Oriental Medicine
Hypothesis
The APOA5 −1131T>C polymorphism is associated with serum lipid levels in Korean subjects classified by Sasang constitution.
Conclusion
The APOA5 −1131T>C polymorphism is linked to lower HDL-C and higher triglyceride levels in certain Sasang constitution groups.
Supporting Evidence
- Subjects with the C allele in So-Yang and Tae-Eum groups had lower HDL-C and higher TG levels.
- The study analyzed 1,619 outpatients from 20 oriental medical hospitals.
- Significant differences in serum lipid profiles were found among Sasang constitution groups.
- The APOA5 −1131T>C polymorphism was associated with serum HDL-C and TG levels.
- Gender differences were observed in the impact of the APOA5 polymorphism on lipid levels.
- The study suggests that Sasang constitution may influence genetic risk factors for lipid metabolism.
- Participants were classified into three groups based on traditional Korean medicine principles.
- Results indicate that genetic factors may help personalize treatment for metabolic diseases.
Takeaway
This study found that a specific gene change can affect cholesterol and fat levels in the blood of Korean people, depending on their body type.
Methodology
The study involved genotyping and analyzing serum lipid levels in 1,619 outpatients from Korean oriental medicine hospitals, classified into three Sasang constitution groups.
Potential Biases
Potential bias may arise from the classification of participants into Sasang constitution groups based on subjective assessments.
Limitations
The study excluded individuals with a history of cardiovascular disease and other major health issues, which may limit the generalizability of the findings.
Participant Demographics
The study included 1,619 individuals, with 595 males and 1024 females, aged approximately 48 years.
Statistical Information
P-Value
3.61E−04
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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