A Study of the Antitumour Activity of Four Triorganophosphinegold(I) Thiolates
1999
Antitumour Activity of Gold(I) Thiolates
Sample size: 60
publication
Evidence: moderate
Author Information
Author(s): David Crump, George Siasios, Edward R. T. Tiekink
Primary Institution: AMRD Operations Pty Ltd, Department of Chemistry, The University of Adelaide
Hypothesis
The study investigates the antitumour activities of four triorganophosphinegold(I) thiolates against a panel of cancer cell lines.
Conclusion
The [Cy3PAu(6-MP)] complex showed the highest cytotoxicity among the tested compounds.
Supporting Evidence
- The [Cy3PAu(6-MP)] complex was the most cytotoxic of the four complexes tested.
- An order of cytotoxicity was established for the 6-MP series: R Cy > Ph > Et.
- Sub-panel selectivity against Leukemia cell lines was found for [Cy3PAu(6-MP)] and [Et3PAu(6-TG)].
Takeaway
The researchers tested four gold compounds to see how well they could kill cancer cells, and one of them worked the best.
Methodology
The complexes were screened against a panel of 60 human tumour cell lines using established protocols.
Limitations
The study did not recommend further action for two of the complexes after repeat screening.
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