Effectiveness of Propiverine for Overactive Bladder Symptoms
Author Information
Author(s): Masumori Naoya, Miyamoto Shintaro, Tsukamoto Taiji, Furuya Seiji, Iwasawa Akihiko, Sato Takashi, Itoh Naoki, Shibuya Akihiko, Oda Toshiro
Primary Institution: Sapporo Medical University School of Medicine
Hypothesis
Does propiverine hydrochloride improve symptoms in patients with overactive bladder who did not respond well to previous anticholinergic treatments?
Conclusion
Propiverine is effective in improving overactive bladder symptoms for patients who poorly responded to other treatments.
Supporting Evidence
- The OAB symptom score improved significantly from 9.0 at baseline to 6.2 at 4 weeks and 6.3 at 12 weeks.
- No increase in postvoid residual urine volume was observed during the treatment.
- The most common side effect was dry mouth, reported by 13.7% of patients.
Takeaway
This study found that a medicine called propiverine helps people with bladder problems when other medicines didn't work well.
Methodology
Patients aged 20 and older with persistent overactive bladder symptoms were treated with propiverine for 12 weeks, and their symptoms were assessed using the OAB symptom score.
Potential Biases
Potential placebo effects and switching between medications may influence outcomes.
Limitations
The study was not a double-blind placebo-controlled trial, which may affect the results.
Participant Demographics
73 patients (29 males and 44 females) with a median age of 71 years.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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