Drosophila phosphopantothenoylcysteine synthetase is required for tissue morphogenesis during oogenesis
2008
Drosophila dPPCS and Tissue Morphogenesis
Sample size: 142
publication
Evidence: moderate
Author Information
Author(s): Floris Bosveld, Anil Rana, Willy Lemstra, Harm H Kampinga, Ody C M Sibon
Primary Institution: University Medical Center Groningen, University of Groningen
Hypothesis
Is dPPCS required for proper tissue morphogenesis during oogenesis?
Conclusion
De novo CoA biosynthesis is required for proper tissue morphogenesis.
Supporting Evidence
- Mutations in dPPCS disrupt female fecundity.
- dPPCS is required for F-actin remodeling during cytoplasmic dumping.
- Disorganized tissue integrity affects Notch and Grk localization.
- Mutations in dPANK and dPPAT-DPCK result in similar patterning defects.
- Reduced fecundity is due to production of aberrant egg chambers.
Takeaway
This study shows that a specific gene in fruit flies is important for making eggs and keeping them healthy.
Methodology
The study used immunohistochemistry and confocal laser scanning microscopy to analyze defects in oogenesis.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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