Analyzing Blood Pressure Changes Over Time
Author Information
Author(s): Kraft Peter, Bauman Lara, Yuan Jin Ying, Horvath Steve
Primary Institution: Harvard School of Public Health
Hypothesis
Different genes may influence blood pressure at different ages.
Conclusion
The study found that different sets of genes regulate blood pressure at different ages.
Supporting Evidence
- Heritabilities for blood pressure at different ages ranged from 27% to 38%.
- Tests indicated significant evidence that different genes affect blood pressure at different ages.
- Linkage analyses replicated previous results on chromosome 17.
Takeaway
This study looked at how blood pressure changes as people get older and found that different genes affect blood pressure at different ages.
Methodology
The study used multivariate variance components analysis on longitudinal blood pressure data from the Framingham Heart Study.
Potential Biases
There is a concern that early withdrawal from the study may be correlated with elevated blood pressure.
Limitations
The analysis did not account for other known risk factors for high blood pressure, and missing data may introduce bias.
Participant Demographics
Participants were from the Framingham Heart Study, including 2885 subjects from 330 pedigrees.
Statistical Information
P-Value
2 × 10-3
Statistical Significance
p < 2 × 10-3
Digital Object Identifier (DOI)
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