A Case of Melanoma That Looked Like Squamous Cell Carcinoma
Author Information
Author(s): Ilaria Proietti, Giulia Azzella, Diana Dirzu, Claudio Di Cristofano, Oreste Bagni, Concetta Potenza, Luca Filippi, Treglia Giorgio
Primary Institution: Dermatology Unit “Daniele Innocenzi”, “A. Fiorini” Hospital, Italy
Conclusion
The patient showed a remarkable response to targeted therapy for cutaneous malignant melanoma, with significant tumor regression observed within weeks.
Supporting Evidence
- The patient had a large, ulcerated tumor that was initially misdiagnosed as squamous cell carcinoma.
- Biopsy confirmed the diagnosis of invasive cutaneous malignant melanoma with a BRAF(V600) mutation.
- Neoadjuvant therapy led to significant tumor size reduction within one week.
- Follow-up PET/CT after three months showed a ΔSUVmax of 51.9%, indicating a strong response to treatment.
- The patient remains under active follow-up with no signs of recurrence.
Takeaway
A woman with a skin cancer that looked like another type of cancer got special medicine that helped her tumors shrink a lot in just a short time.
Methodology
The patient underwent biopsy, PET/CT staging, and neoadjuvant therapy with BRAF and MEK inhibitors.
Limitations
The follow-up period was relatively short, which may limit the assessment of long-term treatment efficacy.
Participant Demographics
The participant was a 66-year-old woman.
Digital Object Identifier (DOI)
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