Epigenetics in Traditional Chinese Pharmacy: A Bioinformatic Study
Author Information
Author(s): Hsin-Ying Hsieh, Pei-Hsun Chiu, Sun-Chong Wang
Primary Institution: Institute of Systems Biology and Bioinformatics, National Central University, Chungli, Taoyuan, Taiwan
Hypothesis
The study investigates the role of epigenetics in the pharmacology of Traditional Chinese Medicine (TCM) prescriptions.
Conclusion
The study found that a significant proportion of Traditional Chinese Medicine formulas interact with epigenetic mechanisms, suggesting a potential therapeutic target.
Supporting Evidence
- 29.8% of Traditional Chinese Medicinals are epigenome- and miRNA-modulating.
- 99% of analyzed TCM formulas are found to interact with epigenetic mechanisms.
- The Monarch medicinals show the most significant epigenome and miRNA interactivity.
Takeaway
This study looks at how certain traditional Chinese medicines can change our genes without changing the DNA itself, which might help in treating diseases.
Methodology
The study analyzed 3294 Traditional Chinese Medicinals and 200 government-approved TCM formulas for their interactions with epigenetics-related proteins.
Limitations
The study does not clarify whether the epigenome-modulating chemicals survive processing and reach target cells.
Statistical Information
P-Value
2.2 × 10−5
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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