Relevance of proliferative and pro-apoptotic factors in non-small-cell lung cancer for patient survival
2000
Factors Affecting Survival in Lung Cancer
Sample size: 150
publication
Evidence: moderate
Author Information
Author(s): Volm M, Koomägi R
Primary Institution: German Cancer Research Center
Hypothesis
Which cellular proliferative and apoptotic factors are most predictive of survival in patients with non-small-cell lung carcinomas?
Conclusion
Patients with high levels of proliferative factors had shorter survival times, while those with apoptotic factors had better outcomes.
Supporting Evidence
- Patients with PCNA-positive carcinomas had significantly shorter survival times than those with PCNA-negative carcinomas.
- Patients with high proliferative activity and low apoptotic factor expression had the shortest survival times.
- Patients with high expression of apoptotic factors had a more favorable prognosis.
Takeaway
This study found that some proteins in lung cancer can help predict how long patients might live, with certain proteins linked to shorter or longer survival.
Methodology
Immunohistochemistry was used to determine protein levels, and flow cytometry assessed cell cycle phases.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website