Green Urine in Dogs Due to Genetic Defect
Author Information
Author(s): Eva Furrow, Jade A. Peralta, A. Russell Moore, Minor Katie M. Hemmila, Candace Guerrero, Charlotte R. Hemmila, Victoria DiCiccio, Jonah N. Cullen, Steven G. Friedenberg, Urs Giger
Primary Institution: College of Veterinary Medicine, University of Minnesota
Hypothesis
Can genetic variants in the BLVRA gene cause biliverdinuria in dogs?
Conclusion
This study identifies the first confirmed cases of biliverdinuria in dogs caused by genetic defects in the BLVRA gene.
Supporting Evidence
- Both dogs had persistently green urine since puppyhood.
- Urinary mass spectroscopy showed increased biliverdin concentrations.
- Whole genome sequencing revealed large deletions in the BLVRA gene in both cases.
Takeaway
Two dogs had green urine because of a rare genetic problem that prevents them from breaking down a substance called biliverdin.
Methodology
The study involved clinical evaluations, urinary mass spectroscopy, and molecular genetic studies to identify genetic variants.
Limitations
The study did not directly measure BLVRA enzyme activity to confirm loss of function.
Participant Demographics
Two adult mixed-breed dogs, one female and one male.
Digital Object Identifier (DOI)
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