Lifespan Models of White Matter in Early Psychosis
Author Information
Author(s): Cirstian Ramona, Forde Natalie J., Zhang Gary, Hellemann Gerhard S., Beckmann Christian F., Kraguljac Nina V., Marquand Andre F.
Primary Institution: Cold Spring Harbor Laboratory
Hypothesis
The study aims to create normative models of white matter organization across the lifespan to understand variations in fractional anisotropy in individuals with early psychosis.
Conclusion
The study found significant white matter heterogeneity in individuals with psychosis that is not captured by traditional group-level analyses.
Supporting Evidence
- The study analyzed diffusion MRI data from over 25,000 healthy individuals.
- Models were developed to capture lifespan trajectories and inter-individual variation in fractional anisotropy.
- Key regions of white matter heterogeneity in psychosis were identified, including the right uncinate fasciculus and thalami.
- The normative models are publicly available for community use.
Takeaway
This study looks at how the brain's white matter changes as people age and helps doctors see how someone's brain might be different from what is normal.
Methodology
The study used diffusion MRI data and multivariate analysis to create normative models and analyze deviations in individuals with early psychosis.
Participant Demographics
Healthy individuals aged 0-100 years from diverse ethnicities.
Digital Object Identifier (DOI)
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