A Complex Case of Acute Liver Failure Following Idiosyncratic Drug-Induced Liver Injury, Potentiated by Herpes Simplex Virus Infection
2024

Acute Liver Failure from Drug Reaction and Virus Infection

publication Evidence: low

Author Information

Author(s): Muacevic Alexander, Adler John R, Soares Ana Raquel, Fiúza Pedro, Rodrigues João, Guisado Orantos Marta, Nascimento Paula

Primary Institution: Unidade Local de Saúde de São José, Lisbon, PRT

Hypothesis

Can acute liver failure be caused by idiosyncratic drug-induced liver injury and herpes simplex virus infection?

Conclusion

The case illustrates a rare instance of acute liver failure following drug-induced liver injury exacerbated by herpes simplex virus infection, leading to high mortality.

Supporting Evidence

  • Acute liver failure is a rare and life-threatening condition.
  • Idiosyncratic drug-induced liver injury is a common cause of acute liver failure.
  • Herpes simplex virus can potentiate liver injury from other causes.

Takeaway

A 73-year-old man got very sick because a medicine he took hurt his liver, and a virus made it worse, which is very dangerous.

Methodology

Case report detailing the patient's medical history, symptoms, diagnostic tests, and treatment.

Potential Biases

Potential bias in reporting due to the nature of a case study.

Limitations

The case is based on a single patient, limiting generalizability.

Participant Demographics

73-year-old male with multiple comorbidities.

Digital Object Identifier (DOI)

10.7759/cureus.74955

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