Migratory Marker Expression in Fibroblast Foci of Idiopathic Pulmonary Fibrosis
Author Information
Author(s): Chilosi Marco, Zamò Alberto, Doglioni Claudio, Reghellin Daniela, Lestani Maurizio, Montagna Licia, Pedron Serena, Ennas Maria Grazia, Cancellieri Alessandra, Murer Bruno, Poletti Venerino
Primary Institution: Department of Pathology, University of Verona
Hypothesis
Uncontrolled activation of the wnt-β-catenin pathway can profoundly influence tissue remodelling in IPF/UIP by triggering pronounced cell migration and proliferation at sites of aberrant expression.
Conclusion
The study suggests that abnormal proliferation and migration of epithelial basal cells overlying myofibroblasts in fibroblast foci play a major role in the pathological remodelling characterising IPF/UIP.
Supporting Evidence
- In UIP, sandwich-foci were present in 28 out of 30 samples, indicating a strong association with the disease.
- SW-FF were often observed in areas of microscopic honeycombing and at the interface between normal lung tissue and areas of dense scarring.
- Abnormal expression of proteins involved in cell migration was identified in the epithelial component overlying fibroblast foci.
Takeaway
The study looked at how certain cells in the lungs of people with a disease called idiopathic pulmonary fibrosis behave differently, which might help doctors understand and diagnose the disease better.
Methodology
The study investigated the immunohistochemical expression of laminin-5-γ2-chain, fascin, and heat-shock-protein-27 in 30 biopsies of IPF/UIP and various control samples.
Participant Demographics
30 previously untreated patients with clinical, radiographic, physiologic and bronchoalveolar-lavage findings consistent with a diagnosis of IPF.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website