Needle-Nerve Contact and Inflammation in Pigs
Author Information
Author(s): T. Steinfeldt, J. Graf, J. Schneider, W. Nimphius, E. Weihe, A. Borgeat, H. Wulf, T. Wiesmann
Primary Institution: University Hospital Giessen-Marburg, Faculty of Medicine, Philipps University Marburg
Hypothesis
High threshold current (1.0 mA) is associated with a reduced likelihood of direct needle-nerve contact compared with low threshold current (0.2 mA), thereby reducing the potential for needle-related nerve injury.
Conclusion
Needle-nerve contact following needle placement may result in aseptic neuroinflammation, but does not cause axonal damage.
Supporting Evidence
- The frequency of needle-nerve contact was 94% at low current compared to 6% at high current.
- The median injury score was significantly higher at low current (2.0) compared to high current (0.0).
- Inflammatory responses were directly related to needle-nerve contacts.
Takeaway
When doctors use needles to help with pain, using a stronger electric current can help avoid hurting the nerves.
Methodology
In anaesthetized pigs, 32 nerves underwent needle placement at low (0.2 mA) or high current (1.0 mA), and histological changes were analyzed after 48 hours.
Potential Biases
The open model may introduce variability in nerve injury assessment compared to a percutaneous approach.
Limitations
The study's observation period of 48 hours may have missed the peak of post-traumatic inflammation.
Participant Demographics
7 female pigs (Deutsche Landrasse) weighing 29–42 kg.
Statistical Information
P-Value
0.001
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website