Determining Asymmetry Thresholds in Anophthalmia/Microphthalmia Using a Three-dimensional Animated Model
2024

Facial Asymmetry in Children with Microphthalmia

Sample size: 72 publication Evidence: moderate

Author Information

Author(s): Romein Emiel J. M.D., Groot Annabel L. W. M.D., Remmers Jelmer S. B.Eng., Lissenberg Birgit Ph.D., Moll Annette C. M.D., Ph.D., Saeed Peerooz M.D., Ph.D., Hartong Dyonne T. M.D., Ph.D.

Primary Institution: Amsterdam UMC, University of Amsterdam

Hypothesis

What are the acceptable thresholds for facial asymmetry in children with congenital microphthalmia and anophthalmia?

Conclusion

Facial asymmetry thresholds for microphthalmia were determined, indicating specific measurements that are deemed unacceptable.

Supporting Evidence

  • A unilateral sunken eye of 6 mm or more was deemed unacceptable.
  • Horizontal palpebral fissure width of ≤79% was found to be significantly unnatural.
  • Downward displacement of the eye greater than 2 mm resulted in a strong desire for correction.

Takeaway

The study found that certain facial differences in children with eye conditions are seen as unnatural, helping doctors decide when treatment is needed.

Methodology

3D models of facial asymmetries were created and rated by respondents using a visual analog scale.

Limitations

The study used only one face model, which may not represent all children with microphthalmia.

Participant Demographics

72 respondents including doctors, medical employees, and laypeople.

Statistical Information

P-Value

<0.001

Statistical Significance

p<0.001

Digital Object Identifier (DOI)

10.1097/IOP.0000000000002711

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