Oestrogen Receptors and Breast Cancer Outcomes
Author Information
Author(s): M.R. Williams, R.I. Nicholson, C.W. Elston, J. Todd, K. Griffiths, R.W. Blamey
Primary Institution: Nottingham City Hospital and Tenovus Institute, Cardiff, UK
Hypothesis
Is there a correlation between oestrogen receptor status and disease-free interval in breast cancer patients?
Conclusion
The study found a significant relationship between oestrogen receptor status and disease-free interval in lymph node positive patients.
Supporting Evidence
- There was a strong relationship between tumour grade and disease-free interval.
- ER positive patients had a different pattern of metastasis compared to ER negative patients.
- The correlation between ER status and disease-free interval was maintained over 5-10 years of follow-up.
Takeaway
This study shows that if breast cancer patients have positive lymph nodes, their oestrogen receptor status can help predict how long they will be free of disease.
Methodology
Analysis of a series of 643 patients with a follow-up of 4-10 years.
Participant Demographics
Patients with primary breast cancer, with a follow-up of 4-10 years.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.001
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